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KMID : 1001920230660030258
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Journal of Korean Neurosurgical Society
2023 Volume.66 No. 3 p.258 ~ p.262
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Pharmacological Management of Germinal Matrix-Intraventricular Hemorrhage
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Chung Jae-Woo
Lee Sang-Koo
Cho Chun-Sung
Kim Young-Jin
Ko Jung-Ho
Yun Jung-Ho
So Jin-Shup
Jung In-Ho
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Abstract
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Germinal matrix-intraventricular hemorrhage (GM-IVH) is among the devastating neurological complications with mortality and neurodevelopmental disability rates ranging from 14.7% to 44.7% in preterm infants. The medical techniques have improved throughout the years, as the morbidity-free survival rate of very-low-birth-weight infants has increased; however, the neonatal and long-term morbidity rates have not significantly improved. To this date, there is no strong evidence on pharmacological management on GM-IVH, due to the limitation of well-designed randomized controlled studies. However, recombinant human erythropoietin administration in preterm infants seems to be the only effective pharmacological management in limited situations. Hence, further high-quality collaborative research studies are warranted in the future to ensure better outcomes among preterm infants with GM-IVH.
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KEYWORD
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Germinal matrix hemorrhage, Cerebral intraventricular hemorrhage, Preterm infant, Erythropoietin
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